Sarit Smolikove

Professor

Research summary

DNA damage repair in C. elegans meiosis

My lab studies different aspects of DNA damage repair in the germline of C. elegans. We mainly use methods related to the fields of genetics and cell biology to study how germ cells maintain genetic integrity. Our current funded projects focus on understanding how DNA-RNA hybrids contribute to DNA damage and affect DNA repair. For more details, please visit the lab's website:
https://www.smolikovelab.com/research

Selected images

Dissected gonad of C. elegans stained with DAPI (chromosomes, blue) and RAD-51 (ssDNA binding protein, green). DSB repair intermediates (RAD-51) are observed throughout meiosis, but peak at mid-pachytene stage. DSBs are created continuously up to mid-late pachytene transition.

Diakinesis chromosomes of wild type (left) and mutants deficient for RNase H (right). Chromosomal fragments in the mutant are indicative of defects in DNA damage repair.

view publications

Research areas

Cell and developmental biology
Genetics

sarit-smolikove@uiowa.edu

319-335-1977

Lab website

PhD, Tel Aviv University (Israel)

Office

University of Iowa
338 Biology Building East (BBE)
210 East Iowa Avenue
Iowa City, IA 52242
United States

Lab

319-335-1214